Anything apart from the two mainstream default harmonicas (Solo-tuned fully-valved chromatic, and un-valved Richter 10-hole diatonic). Alternate tunings, different construction, new functionality, interesting old designs, wishful-thinking... whatever!
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I believe that having a comb slot that is overly large for the reed AND the pitch of the note would result in some response and tuning issues. This is the main reason why Brendan made smaller chambers in his custom combs and using the power plugs.